MOLECULAR BIOLOGY AND GENETICS: FROM GENES TO BIOLOGICAL FUNCTION - 2017/8

Module code: BMS2036

Module provider

School of Biosciences and Medicine

Module Leader

VON SCHANTZ M Prof (Biosc & Med)

Number of Credits

15

ECT Credits

7.5

Framework

FHEQ Level 5

JACs code

C700

Module cap (Maximum number of students)

N/A

Module Availability

Semester 1

Overall student workload

Independent Study Hours: 111

Lecture Hours: 35

Laboratory Hours: 9

Assessment pattern

Assessment type Unit of assessment Weighting
Coursework COURSEWORK PRACTICAL WRITE-UP 30
Examination EXAMINATION 2 HOURS MCQ AND 2 OUT OF 5 ESSAY QUESTIONS 70

Alternative Assessment

If practical components require re-assessment there will be a written exam to assess the underlying principles of the appropriate learning outcomes. This will reflect the material covered in the original assessment and will carry the same weighting.

Prerequisites / Co-requisites

None

Module overview

The purpose of this module is to introduce to the students the ways in which biological function is controlled through control of gene expression at different levels. This module will help the students to both acquire core theoretical core knowledge and key practical skills.

Module aims

Advance the student's understanding of molecular biology especially in relation to Structural analysis, control and cloning of genes

The process of transcription and its regulation

Laboratory analysis of gene expression

Learning outcomes

Attributes Developed
Know and understand the essential elements of the process of gene expression from DNA to biological function, and how it is regulated KC
Understand the concept of genetic variability and how it relates to phenotypic variability C
Grasp the basic concepts and techniques for transcriptomic and proteomic analysis KC
Appreciate the basic principles and applications of animal transgenesiC KC
Be able to perform and interpret basic molecular biology procedures PT
Appreciate the theoretical basis of the above methods KC
Have a basic knowledge and understanding of the genetic basis of cancer KC

Attributes Developed

C - Cognitive/analytical

K - Subject knowledge

T - Transferable skills

P - Professional/Practical skills

Module content

Indicative content includes:

Eukaryotic Gene Structure

Chromosomal Organization of Genes and Noncoding DNA

Genomics: Genome-wide Analysis of Gene Structure and Expression

Structural Organization of Eukaryotic Chromosomes

RNA Polymerase II and the General Transcription Factors Required for Initiation

Regulatory Sequences in Protein-Coding Genes and the Proteins Through Which They Function

Molecular Mechanisms of Transcription Repression and Activation

Regulation of Transcription-Factor Activity

Epigenetic Regulation of Transcription

Other Eukaryotic Transcription Systems

Processing of Eukaryotic Pre-mRNA

Regulation of Pre-mRNA Processing

Transport of mRNA Across the Nuclear Envelope

Cytoplasmic Mechanisms of Post-transcriptional Control

Processing of rRNA and tRNA x 2

Processing of rRNA and tRNA x 2

Genetic Analysis of Mutations to Identify and Study Genes

DNA Cloning and Characterization

Using Cloned DNA Fragments to Study Gene Expression x 2

Using Cloned DNA Fragments to Study Gene Expression x 2

Locating and Identifying Human Disease Genes

Inactivating the Function of Specific Genes in Eukaryotes

Tumour Cells and the Onset of Cancer

The Genetic Basis of Cancer

DNA Repair and Recombination

Cancer and the Misregulation of Growth Regulatory Pathways

Tutorial

Cancer and Mutation of Cell Division and Checkpoint Regulators

Carcinogens and Caretaker Genes in Cancer

Methods of Teaching / Learning

The learning and teaching strategy is designed to:

Provide the basic information to understand the principles and concepts of gene organisation and expression, and methods and approaches employed in cloning genes and stuying their expression, and help the students to acquire hands on experimental skills. Methods and approaches will be taught specifically in the context of the theory (e g in the form of case studies).

 

The learning and teaching methods include:

•      Lectures (30 hours), tutorials (5 hours)

Lab practical sessions (9 hours over two weeks)

 

Assessment Strategy

The assessment strategy is designed to provide students with the opportunity to demonstrate

Understanding of the topic, and ability to find, evaluate and use material to answer the coursework questions.

 

Thus, the summative assessment for this module consists of:

•      Coursework: Practical write-up. Submission deadline 2 weeks after last practical session. Provisional deadlines will be Tuesday week 11  (group 1). Tuesday week 13 (group 2), and Tuesday week 15 (group 3)

•      Examination (2 hours): 50 MCQ and 2 out of 5 essay-type questions

 

Formative assessment and feedback

General feedback about practicals and lectures is provided in the form of feedback tutorials and at the end of practicals sessions for each group. Also, feedback is provided via SurreyLearn through the discussion tool.

Reading list

Reading list for MOLECULAR BIOLOGY AND GENETICS: FROM GENES TO BIOLOGICAL FUNCTION : http://aspire.surrey.ac.uk/modules/bms2036

Programmes this module appears in

Programme Semester Classification Qualifying conditions
Biological Sciences BSc (Hons) 1 Compulsory A weighted aggregate mark of 40% is required to pass the module
Biochemistry BSc (Hons) 1 Compulsory A weighted aggregate mark of 40% is required to pass the module
Biotechnology BSc (Hons) 1 Compulsory A weighted aggregate mark of 40% is required to pass the module
Microbiology BSc (Hons) 1 Optional A weighted aggregate mark of 40% is required to pass the module
Biomedical Science BSc (Hons) 1 Compulsory A weighted aggregate mark of 40% is required to pass the module
Microbiology (Medical) BSc (Hons) 1 Optional A weighted aggregate mark of 40% is required to pass the module
Veterinary Biosciences BSc (Hons) 1 Compulsory A weighted aggregate mark of 40% is required to pass the module
Biomedicine with Data Science BSc (Hons) 1 Compulsory A weighted aggregate mark of 40% is required to pass the module
Biomedicine with Electronic Engineering BSc (Hons) 1 Optional A weighted aggregate mark of 40% is required to pass the module

Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.