INTRODUCTION TO IMMUNOLOGY - 2017/8

Module code: BMS2045

Module provider

School of Biosciences and Medicine

Module Leader

BODMAN-SMITH K Dr (Biosc & Med)

Number of Credits

15

ECT Credits

15

Framework

FHEQ Level 5

JACs code

C550

Module cap (Maximum number of students)

N/A

Module Availability

Semester 2

Overall student workload

Independent Study Hours: 107

Lecture Hours: 17

Tutorial Hours: 5

Laboratory Hours: 9

Assessment pattern

Assessment type Unit of assessment Weighting
School-timetabled exam/test IN-CLASS MINI-TEST 1 - 40 MINUTES 20%
School-timetabled exam/test IN-CLASS MINI-TEST 2 - 40 MINUTES 20%
Practical based assessment LABORATORY REPORT - ELISA PRACTICAL 10%
Examination EXAMINATION - 100 QUESTION MCQ - 120 MINUTES 50%

Alternative Assessment

If practical components require re-assessment there will be a written exam to assess the underlying principles of the appropriate learning outcomes. This will reflect the material covered in the original assessment and will carry the same weighting. Students must hand in a completed laboratory workbook for the Flow Cytometry practical.

Prerequisites / Co-requisites

None

Module overview

The purpose of this module is to provide a conceptual understanding of the key principles of human immunology, including the immune response to infection and foreign antigens. Such an understanding is crucial in many other parts of the program, including the pathogenicity of infectious disease, oncology and pharmacology. It is a prerequisite for modules at FHEQ 6 including BMS3054 (Clinical Immunology and Haematology).

Module aims

Help students become familiar with the terms used in immunology

Develop their understanding of how immunity works by starting from the fundamental components of the reactions involved and building on these to describe the cellular and biochemical events which protect an organism against disease

Provide an understanding and hands-on experience of techniques used in immunology together with experimental design and data analysis

Learning outcomes

Attributes Developed
Have a sound knowledge of the cells and tissues which comprise the immune system KC
Have a thorough command of the basic principles of immunology KC
Be able to illustrate and understand some useful applications of the principles of immunology PT
Have learned the basis of a number of laboratory techniques used in immunology P

Attributes Developed

C - Cognitive/analytical

K - Subject knowledge

T - Transferable skills

P - Professional/Practical skills

Module content

Indicative content includes:

• Theme 1 – Cells and Tissue of the immune system (myloid and lymphoid lineages, bone marrow, thymus, spleen,  MALT, lymph nodes)
• Theme 2 – The innate immune response (complement, phagocytosis, PRRs, PAMPs)
• Theme 3 – Antigens and antigen receptors (antigens, immunogens, antibodies, TCR, BCR, MHC class I and II, antigen presentation)
• Theme 4 – The adaptive immune response: dynamics of the immune response (activation/costimulation/differentiation of T cells, cytokines, germinal centres, class switching, somatic hypermutation/affinity maturation)
• Theme 5 – The adpative immune response: tolerance, hypersensitivity and mucosal immunity (central and peripheral tolerance mechanisms, type I/II/III/IV and V hypersensitivity, mucosal structure and functions, sIgA)
• Practical session on flow cytometry and enzyme-linked immunosorbent assays (ELISAs)

Methods of Teaching / Learning

The learning and teaching strategy is designed to provide the students with a blended-learning approach to a complex subject and to encourage semester-long self-study and deep learning. The module is divided into the 5 themes outlined above, and each theme consists of a 2 hour didactic lecture (in a large group) and a 1 hour small group tutorial (led by one academic and one PhD student for each group of 25-30 students). Each tutorial focuses on one immunological theme and the students undertake guided learning activities that are designed to encourage active learning, peer-to-peer learning, spatial learning and conceptual themes in a more constructivist approach. This cycle is repeated for each of the 5 themes each extending over 2 weeks of the semester. The students take two short (40 minute) summative tests consisting of 20 mixed MCQs/SAQs after themes 2 and 4. These examine their learning of theme 1&2 and 3&4 ILOs. The strategy also incorporates ‘Learning Profiles’ (self-assessed competency matrices) which are designed to help the students guide their self-study as they prepare for the in-course minitests.

The practical component of the strategy is to engage the students with the principles of immunological tests that are used in a wide range of bioscience and clinical research settings. The practicals are also designed to each align with one theme, and provide an alternative learning environment for the concepts that underlie both the experimentation and the techniques.

The learning and teaching methods include:
• Theme lectures – one 2hour lecture per fortnight x5
• Theme tutorials – one 1hour tutorial per fortnight x5
• In-course minitests – A 40min exam after themes 1&2 and 3&4  x2
• Practical sessions – one 3hours, one 6hours
• Practical lecture – two 1hour lectures and a 1hour tutorial on data analysis
• Revision sessions – two 2hour sessions, one of which uses the electronic voting system

Assessment Strategy

The assessment strategy is designed to provide students with the opportunity to demonstrate their conceptual understanding of theoretical and practical immunology within each of the thematic areas as defined by the Learning Profiles. The mini-test format assesses the learning within specific themes, whereas the final MCQ assesses the overall learning in the module.

 

Thus, the summative assessment for this module consists of:

·         Two in-course mini-tests. Each is 40mins long and has 30 mixed MCQ/SAQs. These will be based upon the combined learning in Themes 1&2, and Themes 3&4

·         A practical report of the one-day ELISA practical

·         A final exam consisting of 100 MCQs in 2 hours, examining learning across the 5 themes, as well as theoretical aspects of the practicals

 

Formative assessment and feedback

 

·         There are summative MCQs (10 apiece) and SAQs (2 apiece) available on SurreyLearn after the tutorial for each theme. Students receive immediate feedback on their performance, which contains explanations for each correct answer.

·         The correct and model answers for the in-course minitest MCQs/SAQs respectively are given during the first lecture following the test, giving the students early feedback on their performance.

·         Students complete Learning Profiles in the SurreyLearn throughout the module and the pre-tutorial profile can be used to guide the curricula areas for further exploration.

·         Students receive verbal feedback on their numerical skills and results obtained immediately in the practical sessions. For the half-day Flow Cytometry practical, students must complete a laboratory work book during the session, and immediate group feedback will be given by academics before the session ends. Written feedback on the practical report is given both on the scripts and also in some general feedback which is provided on SurreyLearn

Both of the practical reports are groupwork (flow cytometry in groups of four, ELISA in groups of 2). Currently problems within groups pertaining to group work or group dynamics are reported informally to the module convenor, and students are informed of their right to make a formal complaint about the contribution of a group member to the module convenor in writing (via email)

Reading list

Reading list for INTRODUCTION TO IMMUNOLOGY : http://aspire.surrey.ac.uk/modules/bms2045

Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.