BIOCHEMISTRY - RECEPTORS AND ENERGY METABOLISM - 2017/8
Module code: BMS3052
School of Biosciences and Medicine
THUMSER AE Dr (Biosc & Med)
Number of Credits
FHEQ Level 6
Module cap (Maximum number of students)
Overall student workload
Independent Study Hours: 125
Lecture Hours: 28
Tutorial Hours: 5
|Assessment type||Unit of assessment||Weighting|
|Coursework||COURSEWORK ESSAYS X 2 ( 1000 WORDS EACH )||50%|
|Examination||EXAMINATION - ONE HOUR||50%|
Prerequisites / Co-requisites
Pre-requisites: BMS2035 Biochemistry - Enzymes and Metabolism
This module will address three broad topics, namely Nuclear Receptors, Bioenergetics and Cell Signalling.
To provide an understanding of the molecular mechanisms which underlie metabolic regulation, with a focus on the role of nuclear receptors
To provide a comprehensive analysis of the processes involved in the generation of metabolic energy
To give a detailed account of the molecular processes involved in the mechanism of oxidative phosphorylation
Explain in details the intracellular signalling pathways activated by the plasma membrane and intracellular receptors
To provide detailed information about the nature and the role of the second messengers involved in intracellular signalling pathways
To discuss the importance of cellular signalling pathways in regulating gene transcription in health and disease.
|Demonstrate a sound knowledge of the integration of metabolic pathways||KC|
|Understand the key role of nuclear receptors in the control of metabolism, with specific reference to fatty acids and glucose||KC|
|Understand the similarities and differences between PPAR¿, PPAR ¿/¿ and PPAR¿||KC|
|Identify how plasma membrane and nuclear receptors control cellular function||KC|
|Understand energy metabolism as the biochemical process by which cells obtain and utilize free energy to perform their functions||KC|
|Comprehend the molecular and biochemical mechanisms involved in the synthesis of ATP||KC|
|Identify the role of intracellular signalling pathways activated/initiated by cell surface or intracellular receptors in cell function and behaviour||KC|
|Understand in detail the key intracellular signalling pathways regulated by receptors and second messengers under physiological and pathological conditions||KC|
C - Cognitive/analytical
K - Subject knowledge
T - Transferable skills
P - Professional/Practical skills
Indicative content includes:
• Overview of metabolic pathways and their integration.
• General properties of nuclear receptors.
• Peroxisome Proliferator Activated Receptors (PPAR's): Structure and function.
• Digital skills & essay writing workshop
• Bioenergetics. Basic physical chemistry phenomena. How mitochondria use the energy from substrate oxidation to synthesise ATP. Structure of the electron transport chain. Use of inhibitors, uncouplers and ionophores.
• Oxidative phosphorylation. The chemiosmotic theory. Synthesis of ATP. Molecular architecture of the ATPase. Mitochondrial diseases: Inborn errors of metabolism involving mitochondria.
• Overview of plasma membrane and soluble receptors.;
• G-protein coupled receptors (e.g. glucagon receptor).
• Protein kinase receptors (e.g. insulin).
• Coursework feedback & revision tutorials
Methods of Teaching / Learning
The learning and teaching methods include:
• Workshops: Critical thinking & digital literacy (in collaboration with SPLASH & Library)
• Advised extra reading, including scientific papers and reviews
The assessment strategy is designed to provide students with the opportunity to demonstrate critical thinking, understanding of the taught topics and extra reading
Thus, the assessment strategy for this module consists of:
· Coursework essays (submission of 2 essays from a choice of 3):
§ Essay 1 (Dr Alfred Thumser, linked to Learning Outcomes 1-4)
§ Essay 2 (Dr Avignone –Rossa, linked to Learning Outcomes 5 & 6)
§ Essay 3 (Dr Agouni, linked to Learning Outcomes (4, 7 & 8)
§ Submission deadline 2 weeks after the lectures have been completed
· Final exam (linked to all learning Outcomes)
Formative assessment and feedback:
· Coursework guidance and peer review tutorials
· Feedback on essays (written feedback on essay and one-to-one feedback, as requested)
· Generic post-coursework feedback (on-line)
Feedback on final exam (written feedback on examscripts, one-to-one feedback, as requested, with generic on-line feedback)
Reading list for BIOCHEMISTRY - RECEPTORS AND ENERGY METABOLISM : http://aspire.surrey.ac.uk/modules/bms3052
Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.