CANCER - PATHOGENESIS AND THERAPEUTICS - 2017/8
Module code: BMS3063
School of Biosciences and Medicine
MEIRA LB Dr (Biosc & Med)
Number of Credits
FHEQ Level 6
Module cap (Maximum number of students)
Overall student workload
Independent Study Hours: 122
Lecture Hours: 26
Tutorial Hours: 2
|Assessment type||Unit of assessment||Weighting|
|Coursework||1 X 1000 WORD ESSAY FROM A CHOICE OF TOPICS||15%|
|Coursework||1 X 1000 WORD ESSAY FROM A CHOICE OF TOPICS||20%|
|Examination||2 HOUR EXTENDED ESSAY, STUDENTS TO ANSWER 2 QUESTIONS FROM A CHOICE OF 5||65%|
Prerequisites / Co-requisites
Gives the student a broad understanding of the problem and biological processes underlying cancer and a range of clinically relevant therapeutic approaches. The emphasis is on human studies and data and it fits well within a biomedical sciences program
Provide an understanding of the factors responsible for the development of the most common forms of cancer and students will have an appreciation of the development of cancers from early precancerous lesions to terminal disease from the viewpoint of histopathology
To provide an understanding of how both exogenous and endogenous factors such as diet, viruses and xenobiotics contribute to the development of human cancers.
Demonstrates how we can interfere with the development of cancers both in a chemo-preventative setting, by the use of chemotherapeutic agents and also gain an understanding into the development and use of new targeted therapies based on rational design.
|Understand the factors responsible for the development of the most common forms of cancer||KT|
|Appreciation of the development of cancers from early precancerous lesions to terminal disease from the viewpoint of histopathology||KT|
|Understand how one can interfere with the development of cancers both in a chemo-preventative setting and also by the use of chemotherapeutic agents||KCT|
|Gain an understanding into the development and use of new targeted therapies based on rational design||KCPT|
C - Cognitive/analytical
K - Subject knowledge
T - Transferable skills
P - Professional/Practical skills
Introduction to cancer,: causes, epidemiology, lifestyle + environment
Histopathology of cancer: classification of cancer lesions, the pathologist’s perspective
Development of cancer: disease progression and metastases
Molecular processes underlying cancer: oncogenic changes working singly and in parallel
DNA repair : as a mechanism in cancer development, cancer prone syndromes
Viruses and genetic factors: virally induced cancers, familial cancers, common genetic defects in cancer
Breast, colon and lung cancer:; incidence, disease presentation, associated genetics
Haematological malignancies: Leukaemias and lymphomas
Diet and cancer; carcinogens in the diet, chemoprevention
Cancer therapy: conventional cancer chemotherapy drugs: main classes, mechanisms of action, toxicities, tumour types treated
Drug resistance: the clinical problem and underlying mechanisms
New targeted therapy for cancer: growth factor receptors, oncogene targets, anti-angiogenics, P53 directed therapy, new developments
Clinical Case studies: real cancer patient cases, presentation and subsequent treatment pathways
Methods of Teaching / Learning
The learning and teaching strategy is designed to:
Provide lectures delivered by research active experts in the field of cancer research including clinical oncologists.
Allow integration of knowledge of molecular mechanisms and disease pathogenesis of a variety of cancer types.
Introduce the students to concepts of therapeutic strategy and design within the context of cancer pathogenesis.
The learning and teaching methods include:
Lectures given over a 10-12 week period amounting to 24 hours
One clinical studies lecture given by a medical oncologist
Sessions for advice on scientific writing and the correct use of referencing (for coursework)
A revision tutorial
The assessment strategy is designed to provide students with the opportunity to demonstrate:
Extended reading and analysis of relevant material: first coursework essay is based on a topic that is related to but not directly covered in the lecture series; second coursework essay is more directly based on material covered during lectures.
Engagement in the use of feedback: there will be opportunity for formative feedback prior to the first coursework submission – students can then submit an improved version based on formative feedback.
Engagement in the use of feedback II - Students will learn from feedback given during the first submission and apply what was learned to second submitted coursework.
A depth of understanding and integration of knowledge about molecular mechanisms, cancer pathogenesis and therapeutic approaches in a 2 hour extended examination essay (2 questions answered from a choice of 5).
Thus, the summative assessment for this module consists of:
2 coursework essays from a choice of 3 topics/deadline, 1000 words.
2-hour examination in which students write 2 extended essays from a choice of 5 questions.
Formative assessment and feedback
Individual tutoring on the coursework preparation and the reasons for the marking is provided on request.
Coursework is given back with comments and general points are covered in short tutorial-type periods before lectures.
Reading list for CANCER - PATHOGENESIS AND THERAPEUTICS : http://aspire.surrey.ac.uk/modules/bms3063
Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.