INTRODUCTION TO MATHEMATICAL BIOLOGY - 2017/8
Module code: BMS3090
School of Biosciences and Medicine
ROCCO A Dr (Biosc & Med)
Number of Credits
FHEQ Level 6
Module cap (Maximum number of students)
Overall student workload
Independent Study Hours: 117
Lecture Hours: 22
Laboratory Hours: 11
|Assessment type||Unit of assessment||Weighting|
|Coursework||COURSEWORK - POSTER PRESENTATION||40%|
|Examination||EXAMINATION - ESSAY QUESTIONS - 120 MINUTES||60%|
If the poster requires re-assessment this may be by the submission of an electronic copy of a poster addressing an alternative biological question. If only the poster presentation session was missed this may be carried out in the form of a short, viva style assessment carried out by two members of academic staff.
Prerequisites / Co-requisites
A knowledge of mathematics equivalent to A-level standard is strongly recommended (students without A-level mathematics (or equivalent) are advised to speak with the module co-ordinator before selecting the module).
This module aims at providing students with the problem-solving skills required to construct and solve simple mathematical models of biological systems. Dynamical modelling, in terms of ordinary differential equations, will be introduced, using population dynamics and molecular networks (metabolic reactions and gene regulation) as case studies. The students will be provided with the general techniques to analyse such models, and compute the solution numerically with the aid of a computer. Derivation of qualitative features, relating to steady states analysis, multistability, and oscillatory behaviours, will also be discussed. The module will also provide the students with the opportunity to develop poster presentation skills, and become acquainted with the relevant literature in mathematical/computational biology.
Population dynamics and molecular networks modelling
Identification of steady states, multistability, and oscillatory behaviours
Model solving by computer simulations
Analysis of a number of case studies
|Construct simple models of population dynamics and molecular processes in terms of differential equations|
|Critically analyse these models, extracting dynamical features analytically|
|Solve the models by using direct computer simulations|
|Become acquainted with reading literature in mathematical/computational biology|
|Develop presentation skills by poster presentations|
C - Cognitive/analytical
K - Subject knowledge
T - Transferable skills
P - Professional/Practical skills
Indicative content includes:
1 Revision of Maths
2 Dynamical modelling of biological systems
How to solve differential equations with a computer
3 Population dynamics
Case study: Bacterial growth – Log and stationary phases
Case study: Antibiotic killing – Bacterial persistence
4 Differential equations for molecular networks – The Law of Mass Action
Case study: Michaelis-Menten kinetics – Hill functions
Case study: Gene expression models – Activators and repressors, cooperativity, ‘AND’ and ‘OR’ gates, Competitive activation
5 Steady states and stability
Case study: A genetic model for bacterial persistence
6 Feedback loops – Genetic switches
Case study: Lac operon
Case study: Lambda phage
Case study: Quorum sensing
Case study: Glycolytic oscillations
Case study: Circadian rhythms
8 Introduction to noise in molecular networks
Stochastic differential equations
How to solve stochastic differential equations with a computer
Case study: Stochastic gene expression
Methods of Teaching / Learning
The learning and teaching strategy is designed to teach students the practical and problem solving skills required to tackle mathematically complex biological questions. As such the teaching strategy places equal importance on lecture content and practical skills; for each 1 h “lecture” there is an equivalent computer-based session. In addition to this students will have further learning opportunities afforded by the provision of self-study worksheets and “drop-in” tutorials at which they can discuss their progress.
The learning and teaching methods include:
• 17 h lectures
• 16 h computer-based practical sessions
• 10 h self study with worksheet assignments
• Optional weekly tutorials
The assessment strategy is designed to provide students with the opportunity to demonstrate their ability to recognise biological problems and to select and apply the most appropriate mathematical solutions in order to solve them.
Thus, the summative assessment for this module consists of:
· Poster presentation (40%): each student will present their critical review of an individual paper or topic representing the mathematical solution to a biological question. They will be expected to review the strategies undertaken, including their strengths and limitations. Assessment will occur during a poster presentation session in teaching week 15, in which students will defend and discuss their review with the module organiser and at least one other member of academic staff. The poster will also be submitted electronically via SurreyLearn.
· 2 hour exam (60%): Questions will represent problem-solving exercises in which the students will demonstrate their ability to select and justify appropriate analysis methods. Students will need to select 2 questions from a total of 3.
Formative assessment and feedback
Students will be able to obtain ongoing feedback during the practical sessions, which will provide opportunities to practice approaches discussed in lectures. Further feedback and formative assessment will be available via the comprehensive series of tutorials timetabled within this module; these will give students an opportunity to discuss issues that arise during lectures and practicals, as well as to discuss their solutions to problems.
Reading list for INTRODUCTION TO MATHEMATICAL BIOLOGY : http://aspire.surrey.ac.uk/modules/bms3090
Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.