ADVANCED TECHNOLOGIES IN GENE EXPRESSION - 2017/8
Module code: BMS3092
School of Biosciences and Medicine
MCVEY JH Prof (Biosc & Med)
Number of Credits
FHEQ Level 6
Module cap (Maximum number of students)
Overall student workload
Independent Study Hours: 120
Lecture Hours: 29
|Assessment type||Unit of assessment||Weighting|
|Coursework||COURSEWORK - ESSAY||25%|
|Coursework||COURSEWORK - PROBLEM BASED LEARNING REPORT||25%|
|Examination||EXAMINATION - ESSAY QUESTIONS - 120 MINUTES||50%|
Prerequisites / Co-requisites
BMS2036 Molecular Biology and Genetics: From Genes to Biological Function
This module aims to provide the student with an understanding of the varying strategies taken to produce and deliver important pharmaceutical therapeutic proteins/molecules. The module builds on level 4 and 5 modules that provide a broad background on molecular biology and gene regulation. The module focuses on the application of our knowledge of gene transfer and gene and protein expression to deliver effective pharmaceutical therapies, thus applying our knowledge to real world scientific problems.
To inform students of the range of strategies and tools for the production of therapeutic molecules/proteins
To understand the mechanisms whereby these strategies are implemented
To understand the methods whereby these therapeutics are produced
To understand the advantages and disadvantages of the various approaches
To critically evaluate the appropriate strategy for successful expression
To identify and explore new and novel areas of research in the biotechnology industry.
|Describe the approaches taken to produce pharmaceutical therapeutic proteins/molecules||KCPT|
|Explain the requirements for successful expression of therapeutic proteins/molecules in the different expression systems )||KCPT|
|Critically evaluate the various expression systems||KCT|
|Discuss the advantages and disadvantages of gene therapy versus traditional pharmaceutical drug delivery||KCT|
|Describe the approach of synthetic biology to developing novel strains for the production of biologics||KCT|
C - Cognitive/analytical
K - Subject knowledge
T - Transferable skills
P - Professional/Practical skills
Indicative content includes:
• Molecular biology concepts revisited
• Design and synthesis of expression cassettes (to include bioinformatic tools)
• Microbial recombinant protein production
• Mammalian recombinant protein production
• Production of important pharmaceutical molecules
• Sythetic biology
• Transgenic protein production
• Gene therapy
Methods of Teaching / Learning
The learning and teaching strategy is designed to:
Enable students to be independent learners and to apply their theoretical knowledge of molecular biology to tackling the problems of expressing complex biologics.
The learning and teaching methods include:
• PBL tutorials
• Seminars from external speakers in the field
Contact time will be a total of approximately 30 hours.
The assessment strategy is designed to provide students with the opportunity to demonstrate a clear and deep understanding of the different aspects of applied molecular biology, and to demonstrate their independent learning skills during the course. The PBL will give the students the opportunity to work in a team as well as demonstrate their own writing skills.
Thus, the summative assessment for this module consists of:
• A critical individual essay – Submission deadline week 9
• A PBL based report/essay with group work – Submission deadline week number 14
• An end of semester exam lasting 120 minutes. In the exam students are asked to write 2 essays. One from each section offering a choice of 3 questions covering the entire course work
Formative assessment and feedback
In the PBL group sessions the students will receive formative feedback both as a group and an individual.
Reading list for ADVANCED TECHNOLOGIES IN GENE EXPRESSION : http://aspire.surrey.ac.uk/modules/bms3092
Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.