ADVANCED TECHNOLOGIES IN GENE EXPRESSION - 2017/8

Module code: BMS3092

Module provider

School of Biosciences and Medicine

Module Leader

MCVEY JH Prof (Biosc & Med)

Number of Credits

15

ECT Credits

7.5

Framework

FHEQ Level 6

JACs code

C400

Module cap (Maximum number of students)

N/A

Module Availability

Semester 1

Overall student workload

Independent Study Hours: 120

Lecture Hours: 29

Assessment pattern

Assessment type Unit of assessment Weighting
Coursework COURSEWORK - ESSAY 25%
Coursework COURSEWORK - PROBLEM BASED LEARNING REPORT 25%
Examination EXAMINATION - ESSAY QUESTIONS - 120 MINUTES 50%

Alternative Assessment

N/A

Prerequisites / Co-requisites

BMS2036 Molecular Biology and Genetics: From Genes to Biological Function

Module overview

This module aims to provide the student with an understanding of the varying strategies taken to produce and deliver important pharmaceutical therapeutic proteins/molecules. The module builds on level 4 and 5 modules that provide a broad background on molecular biology and gene regulation. The module focuses on the application of our knowledge of gene transfer and gene and protein expression to deliver effective pharmaceutical therapies, thus applying our knowledge to real world scientific problems.

Module aims

To inform students of the range of strategies and tools for the production of therapeutic molecules/proteins

To understand the mechanisms whereby these strategies are implemented

To understand the methods whereby these therapeutics are produced

To understand the advantages and disadvantages of the various approaches

To critically evaluate the appropriate strategy for successful expression

To identify and explore new and novel areas of research in the biotechnology industry.

Learning outcomes

Attributes Developed
Describe the approaches taken to produce pharmaceutical therapeutic proteins/molecules KCPT
Explain the requirements for successful expression of therapeutic proteins/molecules in the different expression systems ) KCPT
Critically evaluate the various expression systems KCT
Discuss the advantages and disadvantages of gene therapy versus traditional pharmaceutical drug delivery KCT
Describe the approach of synthetic biology to developing novel strains for the production of biologics KCT

Attributes Developed

C - Cognitive/analytical

K - Subject knowledge

T - Transferable skills

P - Professional/Practical skills

Module content

Indicative content includes:

• Molecular biology concepts revisited
• Design and synthesis of expression cassettes (to include bioinformatic tools)
• Microbial recombinant protein production
• Mammalian recombinant protein production
• Production of important pharmaceutical molecules
• Sythetic biology
• Transgenic protein production
• Gene therapy

Methods of Teaching / Learning

The learning and teaching strategy is designed to:

Enable students to be independent learners and to apply their theoretical knowledge of molecular biology to tackling the problems of expressing complex biologics.

The learning and teaching methods include:

• Lectures
• PBL tutorials
• Seminars from external speakers in the field

Contact time will be a total of approximately 30 hours.

Assessment Strategy

The assessment strategy is designed to provide students with the opportunity to demonstrate a clear and deep understanding of the different aspects of applied molecular biology, and to demonstrate their independent learning skills during the course. The PBL will give the students the opportunity to work in a team as well as demonstrate their own writing skills.

 

Thus, the summative assessment for this module consists of:

•      A critical individual essay – Submission deadline week 9

•      A PBL based report/essay with group work – Submission deadline week number 14

•      An end of semester exam lasting 120 minutes. In the exam students are asked to write 2 essays. One from each section offering a choice of 3 questions covering the entire course work

 

Formative assessment and feedback

In the PBL group sessions the students will receive formative feedback both as a group and an individual.

Reading list

Reading list for ADVANCED TECHNOLOGIES IN GENE EXPRESSION : http://aspire.surrey.ac.uk/modules/bms3092

Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.