Module code: MHUM003

Module provider

School of Biosciences and Medicine

Module Leader

GRIFFIN BA Prof (Biosc & Med)

Number of Credits


ECT Credits



FHEQ Level 7

JACs code


Module cap (Maximum number of students)


Module Availability

Semester 1

Overall student workload

Independent Study Hours: 110

Lecture Hours: 18

Tutorial Hours: 4

Assessment pattern

Assessment type Unit of assessment Weighting
Coursework CASE STUDY 40
Examination EXAMINATION - 120 minutes 60

Alternative Assessment

Re-assessments will be a reworking of the original coursework using the same data (or if required, provided class data). 

Prerequisites / Co-requisites

Previous attendance of MHUM001 and MHUM002

Module overview

This module focuses on the role of energy balance and lipid metabolism in cardio-metabolic disease.  Students are taught current evidence based understanding on the interplay of diet, physical activity and lifestyle on the development, prevention and management of metabolic disease.

Module aims

To provide understanding of the variable strength of evidence produced from a hierarchy of experimental studies in nutrition

To evaluate the role of energy expenditure and adaptive thermogenesis in the regulation of energy balance. 

To elucidate the mechanisms involved in the regulation of appetite and food intake and the dietary, behavioural and dietary factors which influence this

To review the cardiovascular risk associated with the insulin resistant conditions of obesity and metabolic syndrome in relation to energy, adipose tissue and lipid metabolism

To detail the metabolic regulation of lipid lipoprotein and fatty acid transport systems, and the impact of fatty liver disease to CVD. Review current evidence for the effects of dietary sterols, fatty acids, carbohydrates and alcohol on energy balance, lipoprotein and fatty acid metabolism in relation to cardio-metabolic disease

To provide an overview of the influence of genetic and epigenetic phenomena on variation in response to diet and nutrient-gene interactions, within the context of personalised nutrition.

Learning outcomes

Attributes Developed
Demonstrated a comprehensive  understanding of the mechanisms of adaptive thermogeneis and energy expenditure in regulating energy balance, and in relation to the development of obesity and metabolic syndrome
Demonstrated an understanding of the control of appetite and its role in regulating energy balance.
An ability to describe and evaluate the integrated metabolic control of lipoprotein pathways and pathogenesis of atherosclerosis. 
An appreciation of  the relationship between diet and cardio-metabolic disease and show a critical awareness of how data on nutrients relates to foods and dietary recommendations.
Demonstrated a comprehensive knowledge of the latest developments in obesity research and management, and of the genetic and epigenetic phenomena underlying the concept of personalised nutrition.

Attributes Developed

C - Cognitive/analytical

K - Subject knowledge

T - Transferable skills

P - Professional/Practical skills

Module content


Introduction to module

From animal studies and epidemiology to evidence based nutritional medicine; understanding the hierarchy of evidence linking nutrition to metabolic disease 

Energy balance and regulation of body weight

Regulation of appetite and food intake, mechanisms of satiety

Energy expenditure and adaptive thermogenesis

Adipose tissue & metabolic aetiology of obesity 

Obesity, Weight loss, relapse, regain. 

Lipid and lipoprotein metabolism II

Cardio-metabolic risk in obesity & metabolic syndrome

Adipose tissue & fatty acid metabolism 

Non-alcoholic fatty liver disease (NAFLD) and steatotic hepatitis (NASH)

Dietary sterols (plant sterols, stanols and cholesterol)

Dietary fatty acids I  (SFA, trans FA, n-6 PUFA, MUFA)

Dietary fatty acids II (n-3 PUFA)

Dietary carbohydrate (glycaemic index & load, and extrinsic sugars)


Nutrition, metabolism & diabetes. 

Translation of metabolic nutrition to dietary recommendations

Concept of personalised nutrition: roles of nutrigenomics & nutrigenetics

Revision of module


Methods of Teaching / Learning

Lectures, seminars and tutorials

Assessment Strategy

The assessment strategy is designed to provide students with the opportunity to demonstrate their acquisition of extensive knowledge on a wide range of topics in metabolic nutrition, understanding of mechanisms by which diet impacts on to cardiovascular health and disease, and to show awareness and ability to interpret the current concepts and controversies in nutritional science.

Thus, the summative assessment for this module consists of:

Course work consisting of written report on a case history (40%)
Written examination (2h): 25 MCQs and 2/4 long essay questions (60%).


Formative assessment

The students will be encouraged to engage in two-way question and answer sessions with the lecturers throughout, and at the end of all formal lectures. Revision tutorials (6h) will revise all of the lecture material and address model answers to passed exam questions.


Feedback: Feedback will be provided on the electronic submission of the case history-based course work. This will take the general form of a description of the positive and negative aspects of the work, and provide an indication of a miniumum of three ways to improve.  There will also be an oral feedback session on the case history-based course work.   

Reading list

Reading list for METABOLIC NUTRITION :

Programmes this module appears in

Programme Semester Classification Qualifying conditions
Human Nutrition MSc 1 Compulsory A weighted aggregate mark of 50% is required to pass the module

Please note that the information detailed within this record is accurate at the time of publishing and may be subject to change. This record contains information for the most up to date version of the programme / module for the 2017/8 academic year.